Adult Mental Health studies

ThrIVe-B – A feasibility study of an adapted Dialectical Behaviour Therapy to see if it would help people to cope with and manage frequent Bipolar mood swings. It was found that it would be possible to run a larger trial, however they would need to reduce the amount of information delivered in the therapy, and to streamline the number of questionnaires. Further detail is available here.

COBRA - Depression is a common, debilitating, and costly disorder. Many patients request psychological therapy, but the best-evidenced therapy—cognitive behavioural therapy (CBT)—is complex and costly. A simpler therapy— behavioural activation (BA)—might be as effective and cheaper than is CBT. We aimed to establish the clinical efficacy and cost-effectiveness of BA compared with CBT for adults with depression. Read the COBRA study here or access the published version by visiting The Lancet website.

Suicide by Middle Aged Men - A national study combining multiple sources of information that provide a detailed account from families, friends and professionals on the stresses men in their mid-life face before they take their lives. Read the published article here.

Homicide by patients with schizophrenia - The study aimed to: Examine socio-demographic, criminological and clinical characteristics and clinical care of people with schizophrenia who commit homicide compared with control cases with schizophrenia who do not commit homicide. Read the published article here.

STEPWISE Trial - Structured lifestyle education for people with Schizophrenia (STEPWISE): mixed methods process evaluation of a group-based lifestyle education programme to support weight loss in people with schizophrenia. Read the published article here.

DiREct - The ‘cohort multiple Randomised Controlled Trial’ (cmRCT) design, has been proposed as a potential solution to poor recruitment into clinical trials and as a way of embedding the principle of research participation into routine health service settings. The DiReCT study used a mixed methods approach to determine the ethical acceptability, the likely overall recruitment yield, the proportion of patients who would consent to being randomly selected to receive new treatments, and the acceptability to clinicians of the cmRCT design. Read the published article here.