Research studies - open for recruitment


The following research studies are currently open for recruitment:

Dementia

AD-Genetics - A genetics study looking to identify unique genes associated with both Early and Late Onset Alzheimer’s disease. View the patient information sheet for the Early Onset arm here and for the Late Onset arm here

SYMBAD - Clinical trial of Mirtazapine versus placebo in the treatment of agitation for people with dementia. View the patient information sheet here.

You can find out more about dementia studies and others on the Join Dementia Research website and also on the University of Exeter dementia research website.

Schizophrenia and Psychosis

ADR - Identifying any genetic predispositions for adverse reactions to Clozapine, to develop individualised drug therapy. View the patient information sheet here

PPiP - An observational study collecting demographic and clinical data, in addition to a blood sample. This study aims to understand if some cases of psychiatric illness are caused by the presence of specific antibodies. View the patient information sheet here

SINAPPS2 - Clinical trial of immunotherapy versus placebo for people whose blood tests show that their psychosis is antibody-associated. 

SCENE 5 - The aim of the SCENE intervention is to improve patients’ quality of life through enhancing their social networks. The SCENE intervention consists of a number of one-to-one contacts between a patient and a mental health professional over a six-month period. Professionals encourage and help patients to engage in activities of the patients’ choosing that involve social contacts. View the patient information sheet here

Relapse Evaluation using Smart Phone Technology (REST) - This study aims to  evaluate the feasibility of predicting relapse in severe mental illness using digital phenotyping data based on smartphone use. View the patient information sheet here

Open Dialogue: Development and Evaluation of a Soicial Network Intervention for Severe Mental Illness (ODDESSI) - The overall aim of the ODDESSI Programme is to assess the effectiveness and cost-effectiveness of Open Dialogue (OD) interventions compared to Treatment as Usual (TAU) for individuals presenting with a mental health crisis to NHS mental health services. For further information please click here

For carers

RCT of COPe-support online resource for carers - If you are supporting a loved one affected by psychosis, aged 18 or above, living in England, and enjoy using internet resources, we would like to tell you more about COPe-support. Please visit our website here or click here for further information.

Perinatal

Molecular investigation into Bipolar Disorder (perinatal arm) - This study is looking at factors that make some women with bipolar disorder more likely than others to experience mood episodes in the postpartum period. We hope this study will lead to better prediction and treatments for these episodes. View the patient information sheet here

ADAGIO - A study comparing two talking therapies for women with depression during pregnancy. It aims to improve psychological treatments for depression during pregnancy. Patients are invited to take part during community midwife clinics or ultrasound dating scan clinics. For more information please email adagio-study@exeter.ac.uk

National Centre for Mental Health (Perinatal Arm) - This study is trying to understand why some people experience problems with their mental health during the perinatal period. The purpose of this study is to collect information and samples for genetic, biological, psychological and clinical research, to look for genes and other factors which make some people more likely than others to become ill. The study hopes to improve understanding of perinatal mental health and help find better treatments in the future. Please click here for further information.

Autism

ASC - The Adult Autism Spectrum Cohort UK, Autism condition in Adulthood - Learning about the lives of adults on the autism spectrum and their relatives in order to create an evidence-based approach to meeting health and social care needs. View the patient information sheet here

Eating disorders
 
Triangle - A randomised controlled trial to examine whether the addition of a patient and carer skill sharing intervention improves long-term patient wellbeing following hospital treatment for anorexia nervosa. View the patient information sheet here
 
Mood disorders
 
Talking Therapies Research Resource - An exciting opportunity to get involved in a major UK research study about psychological wellbeing and talking therapies. View the patient information leaflet here For further information please visit the study website: www.ttrr.org.uk
 

IBER - A new psychological intervention for bipolar disorder, called Imagery Based Emotional Regulation (IBER). IBER is a form of cognitive behavioural therapy (CBT), and is specifically aimed at helping people deal with the anxiety that often occurs in people who suffer from bipolar disorder. IBER is a feasibility study with a two-arm randomised parallel controlled trial design. Participants will either carry on with their usual treatment, or be offered IBER in addition to their usual treatment. View the patient information sheet here

BA-BD: Behavioural Activation for Bipolar Depression - A case series evaluation. Behavioural Activation (BA) is an established approach for people with unipolar depression. It helps people re-establish healthier patterns of activity, but thus far there is little research into offering BA to people with bipolar depression. View the patient information sheet here

 

If you are interested in being involved in participating in research please email dpt.researchrecruitment@nhs.net or phone 01392 674117.

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